Scaling Up Microwave-assisted Solid Phase Peptide Synthesis (SPPS) — From Micromole to Hundreds of Millimoles

Life Sciences, Pharmaceutical, Pharma Manufacturing & Supply Chain, Laboratory Technology,
  • Friday, May 27, 2022 | 11:30am EDT (NA) / 4:30pm BST (UK) / 5:30pm CEST (EU-Central)
  • 60 min

The number of new peptide-based therapeutics is rising, and more peptide generics are entering the market. There is an opportunity to improve output and harness the benefits of microwave-assisted solid phase peptide synthesis (SPPS) in manufacturing. Scaling the synthetic process from the research scale to production scale can be a challenge, particularly in heavily regulated environments.

Automated microwave-assisted SPPS instrumentation can generate production scale peptide active pharmaceutical ingredients (APIs). This is done by the highly reproducible synthesis of multiple batches at hundreds of millimoles with the same benefits as small scale, all while retaining current Good Manufacturing Practices (cGMP) compliance. Modern instrumentation is equipped with features like audit trail tracing, user permission setup and documentation to ease adoption into a regulated facility.

Join this webinar to learn about scaling up the synthesis of research scale peptide-based therapeutics to production in a cGMP environment.



Drew Cesta, Research Scientist, Business Development, CEM Corporation

Drew Cesta is a research scientist at CEM corporation. He obtained his PhD in Medicinal Chemistry from UNC Chapel Hill. His current studies are focused on optimizing the synthesis and purification of peptides and proteins using CEM’s newest microwave-assisted synthesizers and HPLC system.

Message Presenter

Chris Houser, Research Scientist, Product Group, CEM Corporation

Chris Houser is a Research Scientist who works with peptide synthesis instrumentation and focuses on large scale production and the adoption of peptide synthesizers in regulated environments. He specializes in Good Manufacturing Practices (GMP) and assists with GMP testing and product support. He obtained his PhD in Chemistry from Virginia Tech.

Message Presenter

Who Should Attend?

  • Pharmaceutical Scientists/Researchers
  • Academic Researchers interested in peptides and proteins
  • Executives in Biomolecular or Pharmaceutical industry
  • Contract organizations for synthesis and purification
  • Peptide synthesis scientists

What You Will Learn

  • Modern advances in research scale peptide synthesis
  • Scaling up peptide synthesis
  • Adapting peptide synthesis instrumentation for use in cGMP environments
  • Workflow optimization for consistency and performance at the production scale

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CEM Corporation, a private company based in Matthews, North Carolina, is a leading provider of laboratory instrumentation. The Company has subsidiaries in the United Kingdom, Germany, Italy, France, Japan, and Singapore as well as a global network of distributors. CEM designs and manufactures systems for life sciences, analytical laboratories and processing plants worldwide. The Company’s products are used in many industries including pharmaceutical, biotech, chemical and food processing, as well as academic research.

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