Sequence-Specific “Peptoids” for Antifouling, Antibacterial and Self-Assembly Applications

Drug Discovery & Development, Life Sciences, Preclinical,
  • Friday, November 15, 2019 | 11am EST (NA) / 4pm GMT (UK) / 5pm CET (EU-Central)
  • 60 min

Analogous to peptides, non-natural poly(N-substituted glycine) “peptoids” exhibit self-assembly properties and bioactivity that are encoded by the ordering of monomer residues into specific sequences along their polymer backbone. Peptoids differ from peptides in the shift of the sidechain attachment to the backbone amide-nitrogen atoms. They are resistant to protease degradation and have simplified intermolecular interactions.

This webinar highlights recent efforts in exploring solid-phase synthesized peptoids for applications beyond their conventional use in combinatorial drug discovery. The featured speaker will showcase a series of novel properties including the shortest peptoid motifs found to self-assemble into micelles and nanofibrils, “stealth” surface-grafted peptoid brushes that resist biofouling, as well as the modification of known sequences to retain antimicrobial activity for biomedical surface applications. Preliminary results also show that self-assembled peptoid nanosheets can influence protein expression of stem cells under culture. Selected peptoids have been synthesized with a Prelude® X peptide synthesizer.

Speaker

K.H Aaron Lau, PhD, Senior Lecturer (Associate Professor), Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, Scotland, United Kingdom

Dr K. H. Aaron Lau leads his research group in bioinspired molecular interfaces at the University of Strathclyde. He is a senior lecturer (associate professor) in the department of pure and applied chemistry and a founding member of the university’s bionanotechnology initiative. He obtained his Bachelor of Science and Master of Science at Brown University, PhD at the Max Planck Institute for Polymer Research and postdoctoral training at Northwestern University.

His interest is in developing self-assemblies and synthetic surfaces that mimic the nanoscale organization and functionalities observed in natural molecular interfaces. This “biointerfacial” research is driven by both fundamental scientific inquiry and potential applications. The impact of Aaron’s research is in two main areas: i) sequence-specific “peptoids” as novel nanoassemblies, antibacterial surfaces and biomaterials, and ii) surface modification of synthetic materials, especially cellulose, using “polyphenol coatings” for enzyme biocatalysis and biomedical and environmental sensing applications.

His awards include the US NIH National Research Service Award (2011), RSC mobility fellowship (2014), Scottish Crucible (2015) and the Human Frontier Science Program (HFSP) Young Investigator award (2016).

Message Presenter

Who Should Attend?

Professionals focused on:

  • Peptide and Peptidomimetic chemistry
  • Understanding how peptoids are used
  • Biomedical surface applications

Job functions:

  • Scientist II and higher involved with Peptide chemistry
  • Director, peptide therapeutics
  • Biomaterials scientists

What You Will Learn

Attendees will learn about:

  • An overview of non-natural poly(N-substituted glycine) peptoids
  • Applications of solid-phase synthesized peptoids in combinatorial drug discovery
  • Novel properties:
    • Self-assembling peptoid motifs
    • “Stealth” surface-grafted peptoid brushes
    • Sequence modifications for biomedical surface applications
    • Self-assembling peptoid nanosheets

Xtalks Partner

Gyros Protein Technologies

Gyros Protein Technologies enables peptide synthesis and bioanalytical solutions that help scientists increase biomolecule performance and productivity in research, drug discovery, pre-clinical and clinical development, and bioprocess applications.  Our low to mid-scale peptide synthesizer platforms are the new PurePepTM Chorus, PS3, Tribute®, Prelude® X, Symphony® X, and Sonata® XT. These solutions and our chemistries deliver uncompromising purity, flexibility, and quality for discovery and pre-clinical studies of simple to complex multifunctional peptides. Proprietary high performance nanoliter-scale immunoassay platforms, Gyrolab® xPand, Gyrolab® xP workstation and Gyrolab xPlore™, are used by scientists in leading pharmaceutical, biotech, CRO, and CMO companies for bioanalytical applications such as pharmacokinetics/pharmacodynamics, immunogenicity, and quantitating bioprocess-related impurities. Our peptide synthesis and bioanalytical solutions accelerate your discovery, development, and manufacturing of safer biotherapeutics.

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