Solutions For Recombinant Protein Expression

Biotech, Drug Discovery & Development, Life Science, Pharma, Preclinical,
  • Thursday, October 09, 2025 | 11am EDT (NA) / 4pm BST (UK) / 5pm CEST (EU-Central)
  • 60 min

Recombinant protein expression is a cornerstone of modern biotechnology, fueling advances in drug development, molecular biology research and industrial biocatalysis. Challenges with inefficient expression or the accumulation of inclusion bodies can often hinder progress. This webinar will explore proven solutions and innovative strategies to overcome obstacles with protein expression.

Discover preferred strategies and techniques in an exclusive webinar featuring two leading experts in the field specializing in protein engineering and production. The featured speakers have a combined half-century of experience addressing recombinant protein expression issues in many different hosts and are eager to share their expertise.

Redesigning the coding sequence can dramatically impact protein expression efficiency. Learn about the underlying gene design algorithms, computational tools and methodologies that ensure gene sequences are tailored for maximal output in the chosen host system. Alternative promoters and ribosome binding sites help modulate the initiation of transcription and translation, and the choice of leader peptides can dramatically affect the yield of secreted proteins. The webinar will also explore the current limits of recombinant protein expression and strategies to address those limits, providing practical knowledge that can be applied immediately in projects.

Drawing from their combined academic and industry experience, the speakers will discuss strategic decision-making in system selection, expression optimization and scale-up, as well as address common bottlenecks and troubleshooting strategies. Attendees will gain both a technical overview and a seasoned perspective on how to harness recombinant expression platforms to meet the evolving needs of biotechnology and translational research.

Register for this webinar to learn how to improve recombinant protein expression through gene design, host selection and process optimization.

Speakers

Dominic Esposito, Frederick National Laboratory for Cancer Research

Dominic Esposito, PhD, Director, Protein Expression Laboratory, Frederick National Laboratory for Cancer Research

Dr. Dominic Esposito has led the FNLCR Protein Expression team for two decades, supporting the NCI RAS Initiative and NIH investigators with access to recombinant proteins. With deep expertise in multiple host systems and combinatorial cloning, he has produced many thousands of proteins. Dr. Esposito holds a PhD in Biochemistry from Johns Hopkins University and is an author on over 100 publications.

Message Presenter
Mark Welch, ATUM

Mark Welch, PhD, VP, Research & Development, ATUM

Dr. Mark Welch has been with ATUM since 2006. At ATUM, Dr. Welch developed the GeneGPS machine-learning technology for experiment-driven gene expression optimization. He currently leads gene, protein, vector and strain engineering contracts for clients as well as internal new technology development. Prior to ATUM, he held positions at Applied Biosystems, Kosan Biosciences and at Maxygen. Dr. Welch earned his PhD at the University of Colorado at Boulder for studies of the mechanism and evolution of fundamental steps in translation.

Message Presenter
(Moderator) Claes Gustafsson, ATUM

(Moderator) Claes Gustafsson, PhD, Co-Founder, ATUM

Claes is a pioneer of applying machine learning to build better proteins and biologics. He received his PhD in Molecular Biology/Biochemistry from the University of Umeå, Sweden.

Message Presenter

Who Should Attend?

This webinar will appeal to:

  • Protein Scientists
  • Protein Crystallographers
  • Analytical Scientists
  • Drug Developers
  • Biochemists

What You Will Learn

Attendees will gain insights into:

  • The pros and cons of alternative expression hosts
  • Increasing translational efficiency through reloaded gene sequences
  • Optimizing initiation of transcription through promoters and initiation of translation through ribosome binding sites
  • Improving secretion efficiency through leader peptides
  • Other tools for optimal expression

Xtalks Partner

ATUM

ATUM has a 20+ year history of innovation, headquartered in California. ATUM provides contract research and development services for biologics drug discovery and development. Our scope of service spans sequence optimization through cell line development. We use advanced AI, machine-learning and proprietary algorithms to de-risk and accelerate time-to-market for biologics.

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