Interest is increasing in High Resolution Accurate Mass Spectrometry (HRAM) for utilization in all application areas. Current QTOF analyzers that provide resolution >30,000 and mass-to-charge error <5ppm, are generally well suited for HRAM in many aspects. The high spectral acquisition rate of QTOF analyzers provide high quality data with no degradation in resolving power or accuracy, making it an excellent match for high resolution separation technologies.
It is generally true that for TOF analyzers, large size is a requirement for achieving high resolution. Therefore, compact high resolution TOF analyzers are a technological challenge. Mass accuracy is lost if thermal effects aren’t managed. Thermal expansion of the analyzer components will cause peaks to shift when changes in temperature occur, making it difficult to obtain stable intrinsic mass calibration, and thus requires frequent calibration.
The recently introduced SCIEX X500 QTOF, a compact bench-top HRAM mass spectrometer, was designed to address many issues, including size and performance. The X500 QTOF has a novel TOF analyzer that is very compact, yet achieves high resolution and accuracy. Many innovations discovered during the long history of the TOF technology and several important engineering accomplishments are combined to achieve this result. Importantly as well, data acquisition and data processing are also greatly simplified, enabling easy adoption in many research areas, such as biologics characterization, food safety, forensics and environmental testing.
Robert E. Haufler, Ph.D., Staff Scientist, SCIEX
Robert Haufler, Ph.D., has served as Staff Scientist developing time-of-flight technology at the Concord, Ontario, Canada facility since 2006. Dr. Haufler was previously employed at PPD (a CRO in Richmond, Virginia, USA) as Group Leader. Prior to that, Dr. Haufler worked for several startups in mass spectrometry and fullerene research and production. Dr. Haufler earned his Ph.D. at Rice University in Houston, Texas, USA working in the fullerene research group with Professors Richard Smalley and Robert Curl.
Who Should Attend?
Senior professionals working within:
- Analytical Chemistry
- Process Development
- Quality Assurance
- Principal Scientists
- Research Scientists
- Senior Scientists
What You Will Learn
• The development of N-TOF technology for a new generation of bench-top QTOF mass spectrometer
• Technology innovations for achieving high sensitivity, stable and broad linearity of mass calibration
• Streamlined workflow solutions for biologics characterization, food safety, forensics and environmental testing
As a global leader in pioneering mass spectrometry-based technologies, SCIEX has been helping scientists and lab analysts improve the world in which we live for over 40 years. Since successfully commercializing the first triple quadrupole mass spectrometer in 1981, SCIEX has built a reputation of trust among scientists who need to make the right decisions, quickly. Researchers have come to rely on our ingenuity in LC-MS and CE, as well as our experience in software and support from routine testing to the most pressing analytical challenges. Whether you specialize in drug discovery and development, clinical research, forensics, food and environmental testing, SCIEX remains steadfast in our mission to help improve the world in which we live. From our labs to yours, together, we can help see mass spectrometry—and the world—differently.
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