Advanced In Vivo Efficacy Models for Preclinical Success

A comprehensive portfolio of in vivo services plays a critical role in providing essential insights into drug behavior, efficacy and safety. This webinar will highlight how advanced pharmacokinetic/pharmacodynamic (PK/PD) and efficacy models are pivotal in advancing drug candidates from discovery through preclinical development.

Focusing on three key therapeutic areas — oncology/immuno-oncology (IO), immunology and fibrosis — this webinar will share internal as well as customer-approved case studies that demonstrate how preclinical in vivo platforms have supported decision-making and accelerated program timelines. These case studies will be contextualized within the broader industry landscape, underscoring the growing need for predictive and scalable preclinical models.

Building on this foundation, this session will examine how validated and custom in vivo platforms are used to develop disease-relevant models that closely replicate human pathophysiology. Integrated PK/PD studies and biomarker analyses confirm mechanisms of action, while study designs are carefully tailored to meet clinical and regulatory objectives. Complemented by advanced analytics, such as digital histopathology, these approaches provide quantifiable insights, and a collaborative, science-driven process ensures efficient progression toward IND-enabling milestones.

Register for this webinar to explore how PK/PD and in vivo efficacy models can accelerate preclinical success across oncology, immunology, fibrosis and other therapeutic areas.

Speakers

Dr. Malavika Ghosh, PhD, Senior VP and Head, Global Preclinical Research Services, Aragen Bioscience

Dr. Malavika Ghosh leads Aragen Bioscience’s Preclinical Research Services, bringing over 20 years of experience in both academia and industry. Since joining Aragen in 2006, she has established high-quality, client-focused research operations. Dr. Ghosh’s background includes roles at Celliance, Stanford University and diaDexus, with multiple peer-reviewed publications, patents and awards, including recognition as a DOD Breast Cancer Research Program New Investigator.

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Dr. Linh Nguyen, PhD, Director, Oncology & Immunology, Global Preclinical Research Services, Aragen Bioscience

Dr. Linh Nguyen is a trained immunologist with over 15 years of experience in academic research and preclinical drug development, focusing on inflammatory diseases, immune-oncology and cell therapy.  Her work prior to Aragen had contributed to publications in top-tier journals, patents, IND filings and clinical trials. At Aragen, she leads the in vitro and in vivo Oncology & Immunology research services.

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