Advancing Spatial Biology to the Clinic: The Power of Multiplex Immunofluorescence-based Biomarkers for Companion Diagnostics

Life Sciences, Medical Device, Biomarkers, Medical Device Diagnostics, Laboratory Technology, Fundamental Research,
  • Monday, June 10, 2024

This webinar aims to provide insights into immunofluorescence-based biomarker analysis with key considerations for developing a companion diagnostic (CDx). These include avoiding common pitfalls associated with multiplex immunofluorescence and multispectral imaging and successfully harnessing its full potential in the clinical setting.

Recently, there have been many advancements in examining biomarker expression and heterogeneity within the tumor microenvironment using high-throughput technologies. However, current clinical tests for biomarkers often fall short in providing sufficient information to effectively predict treatment response.


Multiplex fluorescence immunohistochemistry and image data analysis have helped uncover meaningful spatial relationships between specific biomarkers, offering valuable insights into patient responses to immune checkpoint inhibitors, antibody-drug conjugates (ADCs) and DNA damage response (DDR) targeted therapies. These techniques have become indispensable for gathering critical data from clinical programs.

As multiplex immunofluorescence techniques mature as an analytical platform, it is important to understand the technology’s fundamentals and its application in assessing response for both mono- and combination therapies.

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This webinar will also cover the critical aspects of working with pharma companies on CDx partnerships and the process of developing pre-market approvals (PMAs) for these diagnostics.

Register for this webinar to explore the latest advancements in multiplex immunofluorescence and CDx partnerships and how these technologies are transforming clinical trials and improving patient outcomes in immuno-oncology.


Pascal Bamford, Akoya Biosciences

Pascal Bamford, Senior Vice President, R&D and Laboratory Operations, Akoya Biosciences

Pascal Bamford joined Akoya Biosciences in October 2021 in the role of Senior Vice President, Research and Development and Laboratory Operations. He possesses deep scientific and operational experience leading teams in developing and implementing successful and innovative products through international regulatory agencies to customers and patients worldwide.

Prior to joining Akoya, he served as Senior Vice President of Products and Services Research and Development at Exact Sciences and has previously held leadership positions at Epic Sciences, Ventana Medical Systems and Monogen.

Pascal earned a PhD in Cell Image Analysis from the University of Queensland, Australia, and a Master’s degree in Engineering from the University of Bristol, UK, and Ecole Nationale Supérieure des Télécommunications, France.

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Mark Landers, Akoya Biosciences

Mark Landers, Vice President, Precision Medicine, Akoya Biosciences

Mark Landers is Vice President of Precision Medicine at Akoya Biosciences and has over 25 years’ experience in oncology diagnostics. Prior to joining Akoya, Mark held leadership positions at Exact Sciences, Guardant Health and Epic Sciences focused on driving precision medicine with pharma partners. Leveraging a strong technical background from years in R&D, he has successfully brought multiple diagnostic tests and companion diagnostics to market.

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Who Should Attend?

This webinar will appeal to professionals in pharma and biotech companies and is relevant to immune-oncology fields, including biotech and biopharma companies looking to develop companion diagnostics for immunotherapy clinical trials. It will benefit decision-makers with responsibilities including, but not limited to:

  • Biomarker program/project management
  • Biomarker Leads
  • Translational/Medicine Biomarker Leads
  • Clinical Biomarker Leads
  • Clinical Development Directors/Medical Directors
  • CDx development

What You Will Learn

Attendees will learn about:

  • How to set up and successfully manage multiplex immunofluorescence (mIF) platforms for CDx and clinical programs
  • Key technical, regulatory and commercial considerations when defining a CDx strategy for mIF
  • Working with pharma companies on CDx partnerships and developing pre-market approvals (PMAs)

Xtalks Partner

Akoya Biosciences

As The Spatial Biology Company®, Akoya Biosciences’ mission is to bring context to the world of biology and human health through the power of spatial phenotyping. The company offers comprehensive single-cell imaging solutions that allow researchers to phenotype cells with spatial context and visualize how they organize and interact to influence disease progression and response to therapy. Akoya offers a full continuum of spatial phenotyping solutions to serve the diverse needs of researchers across discovery, translational and clinical research: PhenoCode™ Panels and PhenoCycler®, PhenoImager® Fusion, and PhenoImager HT Instruments.

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