Single Cell Sequencing: Transform Your Immunology and Cancer Research from Bulk to Single Cell Analysis

Life Sciences, Drug Discovery & Development, Laboratory Technology, Fundamental Research,
  • Wednesday, May 27, 2020

Single cell sequencing has transformed our ability to discern the cellular and molecular makeup of human immune systems and tissues in a unique manner with a level of precision that other “omic” technologies are unable to provide. Coupled with rigorous analysis, this technology is able to identify rare cell populations/subtypes and provide novel insights about pathways and thus transform our ability to characterize human disease, as well as, drug targeting through a deeper understanding of underlying biology.

Single cell RNA sequencing, in particular, allows a researcher to identify complex heterogeneous cell types at a molecular level. For infectious disease research, single cell data analysis helps us understand our immune system responses to different pathogens. In cancer studies, this means a deeper understanding of the ecosystems of malignant cells; providing better resolution of the tumor microenvironment. This ultimately helps to more efficiently and effectively treat diseases by different modalities such as cell-based and immuno-therapies.

In this webinar, please join our invited guest speakers as we discuss the advantages and challenges of single cell sequencing and how this technology has helped deliver a deeper understanding of disease and cellular biology in unique and complementary ways to other omics technologies.

Speakers

Jeffrey Wallin, PhD, Sr. Director Biomarkers, Gilead Sciences

Jeffrey Wallin is a trained immunologist who has worked primarily in the areas of immuno-oncology and infectious disease. He currently leads a biomarker team at Gilead that studies human host responses to HIV and HBV using several methodologies including single cell sequencing approaches.

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Rosha Poudyal, Science & Technology Advisor, 10x Genomics

Rosha Poudyal earned her PhD in biochemistry and molecular biology and pursued postdoctoral research where she employed single-molecule techniques to unravel cancer epigenetics and chromatin biology. For the past year and a half, Rosha worked at 10x Genomics as a Field Application Scientist where she provided support to a wide user base in academia and industry. She is currently one of the Global Science and Technology Advisors at 10x Genomics and is responsible for providing scientific guidance on adapting and utilizing 10x solutions in various research areas.

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Kristof O'Connor, Sales Executive, 10x Genomics

Kristof O’Connor has been serving as a local Sales Executive in the New England area at 10x Genomics since February 2020. Prior to joining 10x Genomics, Kristof has held various sales and marketing positions across the east coast with Boston/Cambridge area being his base of operations. He has focused heavily in the life science/genomics sector in the last decade selling lab equipment or instrumentation from organizations such as MGI Technologies (a BGI company), SeraCare Life Sciences Clinical Genomics group, Tecan lab automation, and Eppendorf lab automation teams. Kristof holds a B.S. in Chemistry from the University of Massachusetts at Amherst with a focus on organic synthesis and polymer material science research.

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http://Hongye%20Sun,%20WuXi%20NextCODE

Hongye Sun, PhD, Scientific Fellow, WuXi NextCODE

Hongye Sun is a Venture Partner for 6 Dimensions Capital and serves as a Scientific Fellow for WuXi NextCODE. Dr Sun is the former CTO of WuXi NextCODE Genomics, Inc. where he joined from Life Technologies (now Thermo Fisher) in 2011. He established the WuXi Genome Center, the first CLIA-certified Next Generation Sequencing lab in China to integrate genomics into drug discovery, clinical development and personalized medicine. He was in charge of the technology development, operation and marketing and sales for the Genomic Business unit. After the merging of the Genomic Center with NextCODE Health in 2015, he served as the global CTO.

In 2018, he moved back to the US and served as CTO for WuXi NextCODE and established the US lab for clinical testing and services. When at Life Technologies, he spent over ten years in the San Francisco Bay Area working on new sequencing technology development and managing a multi-disciplinary team including biophysicists, chemists, biochemists, nanofabrication engineers, optical engineers and software engineers to develop a real-time single molecule DNA sequencing technology. Dr Sun did his post-doctoral fellowships in chemistry and chemical biology at Harvard University and the University of Kansas and received his PhD from Peking University.

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Who Should Attend?

Industry: Pharma, Biotech, Government, Academic Medical Centers

Job titles include:

  • Head, Translational Medicine
  • Director Translational Biology
  • VP Translational Biology
  • R&D Dir., Platform
  • Global Director, Cell & Gene Therapies Business 
  • Senior or Principal Researcher
  • Senior or Principal Investigator
  • Senior or Principal Scientist
  • Head of Discovery Sciences
  • Senior Director, Early Development and Translational Sciences
  • Executive Vice President, Research and Development
  • Director
  • Executive Director

 

What You Will Learn

In this webinar, attendees will learn about:

  • Different types of single cell sequencing but with a focus on single cell RNA sequencing
  • An understanding of how single cell RNA sequencing can offer a unique lens into a cellular / tissue microenvironment
  • How single cell sequencing can complement other “omics” strategies
  • An appreciation for how single cell sequencing can help when dealing with low patient numbers as in the case of some clinical trials
  • The challenges of working with different cell types
  • An appreciation for a direct application of single cell RNA sequencing as illustrated by Dr Wallin

 

Xtalks Partner

WuXi NextCODE

WuXi NextCODE is a global genomic data and insights company that serves the world’s leading life sciences companies including biotechnology, pharmaceutical companies and medical research centers. Our partners all use insights from genomic data to improve health. Our capabilities include providing access to population-scale patient cohorts for research, next generation sequencing (NGS) through CLIA/CAP GCP labs globally, and a team of the world’s leading A.I. and genomic analysis experts and technologies for organizing, mining and sharing genomic and disease biology data. Visit us on the web at wuxinextcode.com.

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