Discover an informative webinar in which the speaker will be discussing the latest findings on cilia’s biomarker potential and its application in the clinic.
Cilia are microtubule-based organelles found in most cells in the body. Endothelial cilia are a known blood flow sensor and studies have identified that upon high shear stress, endothelial cilia get dismantled, a process called deciliation.
On deciliation, proteins found inside a microtubule-based organelle called cilia are released into the blood. When these proteins from inside the cilium are spilled into blood, they stick to cells in blood, which can be detected by flow and immunoassays. These ciliary proteins can be observed in conditions where the underlying vasculature is weakened due to disturbed flow.
In some cases, ciliary protein levels correlate with recovery from the blood–brain barrier damage. Based on recent scientific discoveries, assays are being developed for detecting ciliary proteins in human blood and other body fluids. Moreover, predictions for long-term or short-term outcomes are expected to administer appropriate clinical care.
Register for this webinar today to explore the latest developments related to the biomarker potential of cilia and their potential clinical applications.
Speaker
Ramani Ramchandran, PhD, Professor, Medical College of Wisconsin; President and Founder of CIAN, Inc.
Professor Ramani Ramchandran completed his PhD in Biochemistry and Molecular Biology at Augusta University. He undertook a research fellowship at Harvard Medical School from 1997 to 2002. In 2002, upon receipt of National Cancer Institute Scholar Award, he moved to National Institutes of Health (NIH) to start his first independent lab.
He was recruited to the Medical College of Wisconsin (MCW) in 2007 as an Associate Professor where he has risen through the academic ranks to the position of professor in the Department of Pediatrics, Children’s Research Institute.
He has had numerous leadership positions at MCW, including the current position of the Director of the Medical Student Summer Research Program. He has published over 100 articles and is considered a leading expert on vascular biology. His research has been continuously funded from NIH since 2002. In 2023, Professor Ramchandran founded CIAN Inc., a company dedicated to developing ciliary proteins as a biomarker for altered blood flow. He is active in both academic and industry-related activities.
Message PresenterWho Should Attend?
This webinar will appeal to those with the following job titles or working in the following fields:
- Graduate Students/Lab Technicians/Research Fellows interested in basic, clinical and translational research
- Researchers interested in biomarkers
- CEOs/CSOs interested in biomarker technologies
- Principal Scientist/Principal Investigator
- Biopharma/Biotech
What You Will Learn
Attendees will learn about:
- The role of endothelial cilia as blood flow sensors and how the process of deciliation leads to the release of ciliary proteins into the bloodstream
- The development of assays, such as flow and immunoassays, for detecting ciliary proteins in human blood and other body fluids
- How the measurement of ciliary proteins can help predict short-term and long-term patient outcomes
Xtalks Partner
GenScript
GenScript is the leading contract research organization in the world providing gene, peptide, protein, CRISPR, and antibody. Since its foundation in 2002, GenScript has grown exponentially through partnerships with scientists conducting fundamental life science research, translational biomedical research, and early stage pharmaceutical development. The company is recognized as having built a best-in-class capacity and capability for biological research services, encompassing gene synthesis, peptide synthesis, custom antibody and protein engineering, and in vitro and in vivo pharmacology – all with the goal to Make Research Easy.
You Must Login To Register for this Free Webinar
Already have an account? LOGIN HERE. If you don’t have an account you need to create a free account.
Create Account